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  • Title: Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (I).
    Author: Khouili M, Guillaumet G, Coudert G, Pujol MD.
    Journal: Farmaco; 1996 Mar; 51(3):175-84. PubMed ID: 8688139.
    Abstract:
    The synthesis of a new series of alpha- and beta-adrenergic blocking agents 14 is described. The affinity and selectivity of these compounds for alpha, beta 1 and beta 2-adrenoceptors were studied in comparison with those of WB-4101 and propranolol. The derivatives 14cx and 14dx are more potent beta 1-blockers than propranolol.
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