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  • Title: Sickle cell anemia and trait in a population of southern India.
    Author: Brittenham G, Lozoff B, Harris JW, Sharma VS, Narasimhan S.
    Journal: Am J Hematol; 1977; 2(1):25-32. PubMed ID: 868866.
    Abstract:
    In an ethnic group in southern India, the Irula, seven individuals with sickle cell anemia were found to manifest only mild illness. Although a relatively high level of fetal hemoglobin was present in one, none of the factors thought to ameliorate the course of sickling disorders could be identified in the remaining six. In a random population survey, sickle hemoglobin was found in 90 of 292 Irula (31%). In those with sickle cell trait, the proportion of sickle hemoglobin in hemolysates (mean = 26%, range 19-32%) was substantially lower than that reported for any other population.
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