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  • Title: An electron microscopic study of the processes of nerve regeneration after lyophilized nerve homografting.
    Author: Takasaki Y, Noma H, Ling QD, Nanpo H, Taniguchi M, Masaki H, Sugiyama N, Sasaki K.
    Journal: Bull Tokyo Dent Coll; 1995 Aug; 36(3):115-20. PubMed ID: 8689751.
    Abstract:
    The objective of the present study was to investigate the role of the Schwann cell basal lamina in nerve regeneration. To achieve this goal, we observed the process of axonal regeneration within a lyophilized nerve graft, in which only the basal lamina of the Schwann cell persisted. Sciatic nerves were removed from rats and lyophilized to kill the Schwann cells and other components. These grafts were transplanted to rat sciatic nerve defects. The rats were then killed after lapses of time. We observed the processes of axonal regeneration using a transmission electron microscope. Regeneration of axons along the inner surface of the Schwann cell basal lamina was clearly seen. These results suggest that, if tubular basal laminae persist, Schwann cells are not always necessary, and axonal regeneration can be induced in the direction toward the basal lamina.
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