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  • Title: Multiple keratoses and squamous carcinoma after PUVA treatment of vitiligo.
    Author: Buckley DA, Rogers S.
    Journal: Clin Exp Dermatol; 1996 Jan; 21(1):43-5. PubMed ID: 8689768.
    Abstract:
    PUVA is known to be carcinogenic when used in the treatment of psoriasis. To date skin cancer has not been demonstrated after PUVA treatment of vitiligo. We report a patient in whom multiple squamous cell carcinomata and keratoses developed in vitiligo areas after a prolonged course of PUVA. PUVA therapy of vitiligo induces repigmentation of affected skin in some patients. An increased frequency of cutaneous neoplasms in depigmented areas is a potential hazard, as in these sites the photoprotective effect of melanin is lacking.
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