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  • Title: The role of calcium in the regulation of apoptosis.
    Author: McConkey DJ, Orrenius S.
    Journal: J Leukoc Biol; 1996 Jun; 59(6):775-83. PubMed ID: 8691060.
    Abstract:
    The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanisms may also he involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.
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