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  • Title: Three-dimensional reconstruction of benign lymphoid aggregates in bone marrow trephines.
    Author: Salisbury JR, Deverell MH, Cookson MJ.
    Journal: J Pathol; 1996 Apr; 178(4):447-50. PubMed ID: 8691325.
    Abstract:
    Distinguishing between deposits of low-grade non-Hodgkin's lymphoma and benign lymphoid aggregates in bone marrow trephine sections is a recognized problem in haematopathology. To test the hypothesis that benign lymphoid aggregates do not make contact with a trabecular surface, three-dimensional models were constructed of five serially sectioned bone marrow trephines, containing a total of 19 lymphoid aggregates known to be benign. The computer-generated images showed that benign lymphoid aggregates were located in the central marrow space and did not become paratrabecular. This suggests that a paratrabecular location may help in some cases to distinguish deposits of low-grade non-Hodgkin's lymphoma from benign lymphoid aggregates.
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