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  • Title: [Neoplasias in hematopoietic tissues].
    Author: Kamada N, Ishimae M.
    Journal: Nihon Rinsho; 1996 Jun; 54(6):1626-30. PubMed ID: 8691620.
    Abstract:
    Leukemia-specific chromosomal aberrations are the most reliable tumor markers. Although chromosome analysis is a powerful diagnostic tool, some aberrations like monosomy 7 in AML, 15; 17 translocation in APL and trisomy 12 in CLL are not adequately detected. Fluorescence in situ hybridization is a recent method to detect specific genetic alteration in both interphase and mitoic cells and overcomes the disadvantages of conventional cytogenetics, Southern blotting and RT-PCR. In this manuscript, the advantages and limitations of the methods used for detecting leukemia/lymphoma specific chromosomal markers were discussed.
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