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  • Title: The effects of anabolic androgenic steroids on serum ubiquinone and dolichol levels among steroid abusers.
    Author: Karila T, Laaksonen R, Jokelainen K, Himberg JJ, Seppälä T.
    Journal: Metabolism; 1996 Jul; 45(7):844-7. PubMed ID: 8692019.
    Abstract:
    We measured serum ubiquinone and dolichol concentrations in 13 men while they abused anabolic androgenic steroids (AAS) and during the following withdrawal period. Serum total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol and triglycerides were also determined. AAS administration increased serum ubiquinone by 68% (P < .001) and decreased serum dolichol by 30% (P < .002). Both nonsterol isoprenoid levels in plasma correlated with the AAS dose, ubiquinone positively (P < .001) and dolichol negatively (P < .002). When the subjects were taking steroids, the ubiquinone to LDL ratio was 42% higher than during the withdrawal period. In conclusion, our study suggests that AAS have an influence on the by-products of the mevalonate pathway.
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