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  • Title: The effect of some 2-substituted quinolines isolated from Galipea longiflora on Plasmodium vinckei petteri infected mice.
    Author: Gantier JC, Fournet A, Munos MH, Hocquemiller R.
    Journal: Planta Med; 1996 Jun; 62(3):285-6. PubMed ID: 8693048.
    Abstract:
    We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.
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