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  • Title: Activation of mitogen activated protein kinase in dolichyl phosphate-induced apoptosis in U937 cells.
    Author: Dohi T, Yasugi E, Oshima M.
    Journal: Biochem Biophys Res Commun; 1996 Jul 05; 224(1):87-91. PubMed ID: 8694838.
    Abstract:
    Exogenous dolichyl phosphate (Dol-P) induced apoptosis in the human monoblastic leukemia cell line U937 within 4 hours. Phosphorylation of p42 mitogen-activated protein kinase (MAP kinase) increased prior to DNA fragmentation. MAP kinase activation occurred within 5 min, and the maximum response was observed at 30 min. Inhibition of tyrosine phosphorylation of MAP kinase by herbimycin A resulted in complete inhibition of DNA fragmentation and partial inhibition of cell death. These results suggested that Dol-P-induced apoptosis is mediated by the MAP kinase cascade.
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