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  • Title: Alterations in the systemic acid-base status and blood gas dynamics during progressive hypocalcaemia in cow calves.
    Author: Setia MS, Singh A, Kahlon RS, Randhawa SS.
    Journal: Indian J Exp Biol; 1996 Apr; 34(4):375-6. PubMed ID: 8698428.
    Abstract:
    Hypocalcaemia, induced in cow calves by slow infusion of Na2EDTA for 6 hr, led to biphasic changes in acid-base status. Decrease in ionized plasma Ca2+ concentration upto 0.82 +/- 0.06 mmole 1(-1) was associated with metabolic alkalosis. Further decrease in ionized plasma Ca2+ concentration (0.61 +/- 0.09 mmole 1(-1)) led to metabolic acidosis, superimposed by a respiratory component. There was significant decrease in oxygen tension and saturation of arterial blood as well as impaired uptake of oxygen by peripheral tissues and pulmonary blood.
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