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  • Title: Effect of vitamin K2 on experimental calcinosis induced by vitamin D2 in rat soft tissue.
    Author: Seyama Y, Horiuch M, Hayashi M, Kanke Y.
    Journal: Int J Vitam Nutr Res; 1996; 66(1):36-8. PubMed ID: 8698544.
    Abstract:
    The effect of vitamin K2 on calcium (Ca) and inorganic phosphorus (P) levels in the aorta and kidney obtained from experimental calcinosis induced by vitamin D2(2.5 x 10(5) I.U./ kg b.w.) of male rats was investigated. A high dose of vitamin K2 (100 mg/kg b.w.) inhibited the increase in the aortic Ca and P or in the renal Ca and P induced by vitamin D2, and a low dose of vitamin K2 (10 mg/kg b.w.) showed the same tendency, but the degree of the efficacy was small. It may be suggested that a high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. Therefore, a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.
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