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  • Title: Human immunodeficiency virus type 1 kinetics in lymph nodes compared with plasma.
    Author: Lafeuillade A, Poggi C, Profizi N, Tamalet C, Costes O.
    Journal: J Infect Dis; 1996 Aug; 174(2):404-7. PubMed ID: 8699075.
    Abstract:
    As lymphoid organs are the major reservoir of human immunodeficiency virus type 1 (HIV-1), the rates at which HIV-1 RNA decreases from the plasma and from a series of lymph node biopsies from 4 patients treated with a combination of zidovudine, didanosine, and lamivudine were measured. The concentrations of HIV-1 RNA in the plasma and in lymph nodes declined exponentially, with mean half-lives of 1.88 +/- 0.86 days for plasma and 6.01 +/- 3.44 days for lymph nodes. These data show that most of the HIV-1 in lymphoid organs is due to the infection of new cells and demonstrate that a triple-drug combination is able to target this compartment.
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