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  • Title: Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
    Author: Haraguchi H, Ohmi I, Sakai S, Fukuda A, Toihara Y, Fujimoto T, Okamura N, Yagi A.
    Journal: J Nat Prod; 1996 Apr; 59(4):443-5. PubMed ID: 8699190.
    Abstract:
    The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.
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