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  • Title: Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.
    Author: Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB.
    Journal: Nature; 1996 Jul 11; 382(6587):133-8. PubMed ID: 8700202.
    Abstract:
    Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.
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