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  • Title: Cdc25 cell-cycle phosphatase as a target of c-myc.
    Author: Galaktionov K, Chen X, Beach D.
    Journal: Nature; 1996 Aug 08; 382(6591):511-7. PubMed ID: 8700224.
    Abstract:
    The product of the proto-oncogene c-myc, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc, cdc25A, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires cdc25A. These findings indicate that cdc25A is a physiologically relevant transcriptional target of c-myc.
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