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  • Title: [A comparative evaluation of different immunological reactions in the diagnosis of pseudotuberculosis].
    Author: Burgasova OA, Kuleshova LB, Tseneva GIa, Iushchuk ND, Kukhtevich EV, Kuznetsov VF, Bondarenko VM.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1996; (2):48-51. PubMed ID: 8701656.
    Abstract:
    To study humoral response in patients with the generalized form of pseudotuberculosis, the agglutination test, the passive hemagglutination test and the complement fixation test with antigen obtained from "Virion" (Switzerland) were used. The study of the dynamics of antibody formation to outer membrane proteins (OMP) and Yersinia pseudotuberculosis (pYV+ and pYV-) lipopolysaccharide (LPS) revealed that the synthesis of antibodies to OMP, controlled by inv gene, exceeded the synthesis of antibodies to LPS at all periods of the disease, which determined the necessity of further study of the role of OMP in pathogenesis and in the formation of humoral response. On the basis of the study of the occurrence of antigens a high diagnostic effectiveness the enzyme immunoassay for the detection of Y. pseudotuberculosis antigens, mainly at the first stage of the disease, was noted.
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