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  • Title: [Effects of nicorandil on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats].
    Author: Wang HX, Wang WX.
    Journal: Zhongguo Yao Li Xue Bao; 1995 Sep; 16(5):477-80. PubMed ID: 8701774.
    Abstract:
    AIM: To study the anti-arrhythmic mechanism of nicorandil (Nic). METHODS: The myocardial cells of neonatal rats were cultured and effects of Nic on spontaneous beating and action potential of cultured myocardial cells were observed. RESULTS: Nic 32 mumol L-1 and 160 mumol L-1 decreased the spontaneous beating rates of cultured myocardial cells of neonatal rats. Nic 64 mumol L-1 prevented the beating rats induced by CaCl2 1 mmol L-1 and isoproterenol 2 mumol L-1. Nic 32 and 160 mumol L-1 reduced the amplitude, maximal rate of rise, and shortened APD50 and APD90 repolarization. Nic prolonged the spontaneous sinus cycle length. CONCLUSION: The antiarrhythmic mechanism of Nic is related to its direct effects on the myocardial cells.
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