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  • Title: Vincristine-induced alterations in Schwann cells of mouse peripheral nerve.
    Author: Djaldetti R, Hart J, Alexandrova S, Cohen S, Beilin BZ, Djaldetti M, Bessler H.
    Journal: Am J Hematol; 1996 Aug; 52(4):254-7. PubMed ID: 8701942.
    Abstract:
    The sciatic nerve of C57Bl mice was examined with a transmission electron microscope to study the ultrastructural alterations in Schwann cells following treatment with escalating doses of vincristine. Results indicated that the drug exerts a dose-related effect. Total doses up to 8 micrograms/mouse did not cause any visible damage to Schwann cells. Higher doses induced not only damage to individual cells, but also affected a greater percentage of them. The myelin sheath was the most affected organelle. Schwann cells of myelinated fibers showed greater damage than those of unmyelinated fibers.
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