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Title: NE1: a new neutrophil specific antigen. Author: Claas FH, Langerak J, Sabbe LJ, van Rood JJ. Journal: Tissue Antigens; 1979 Feb; 13(2):129-34. PubMed ID: 87023. Abstract: The sera of three children with chronic benign neutropenia, due to anti-neutrophil antibodies, were studied with respect to their antibody specificity. This was done by screening the sera against a panel of leukocyte donors in the EDTA micro-agglutination test and in the indirect fluorescence test. Two of the sera contained antibodies against the known neutrophil-specific antigen NA2. The third serum was directed against a new neutrophil-specific antigen. Genetic analysis showed no correlation between this antigen and the already known neutrophil-specific antigens: 9A, NA1, NA2, NB1, and NC1. In the Dutch population the frequency of the new antigen, tentatively called NE1, is 23%, which gives a gene frequency of 0.12.[Abstract] [Full Text] [Related] [New Search]