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Title: A yeast transcriptional stimulatory protein similar to human PC4. Author: Henry NL, Bushnell DA, Kornberg RD. Journal: J Biol Chem; 1996 Sep 06; 271(36):21842-7. PubMed ID: 8702984. Abstract: A yeast protein has been identified that stimulates basal transcription by RNA polymerase II, binds both single- and double-stranded DNA, and interacts with both a general transcription factor and a transcriptional activator. Phosphorylation appears to regulate these interactions. The gene for the transcriptional stimulatory protein, termed TSP1, was cloned and found to be dispensable for yeast cell viability. The deduced amino acid sequence is similar to that of mammalian coactivator protein PC4.[Abstract] [Full Text] [Related] [New Search]