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  • Title: High lactate dehydrogenase level is associated with an adverse outlook in autografting for Hodgkin's disease.
    Author: Lumley MA, Milligan DW, Knechtli CJ, Long SG, Billingham LJ, McDonald DF.
    Journal: Bone Marrow Transplant; 1996 Mar; 17(3):383-8. PubMed ID: 8704691.
    Abstract:
    Forty-two patients with relapsed or refractory Hodgkin's disease (HD) were treated with high-dose chemotherapy (BEAM regimen) followed by autologous bone marrow and/or peripheral blood progenitor cell (PBPC) rescue. There was one procedure-related death and the overall response rate at 6 months was 88% (95% confidence interval 78-98%). The 2 year overall and event-free survival was 81% (95% confidence interval 65-96%) and 74% (95% confidence interval 58-89%) respectively. Median follow-up was 33 months. The use of PBPC instead of marrow resulted in a significant shortening of the time to engraftment (P < 0.01). Multivariate analysis identified the pre-transplant LDH level as a highly significant factor in predicting overall survival (P = 0.007). The BEAM regimen is an effective conditioning schedule that is well tolerated but patients with a raised LDH at the time of transplant remain at high risk of early relapse and death due to disease.
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