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  • Title: Clinical experience with a new recombinant hepatitis-B vaccine in previous non-responders with chronic renal insufficiency.
    Author: Haubitz M, Ehlerding G, Beigel A, Heuer U, Hemmerling AE, Thoma HA.
    Journal: Clin Nephrol; 1996 Mar; 45(3):180-2. PubMed ID: 8706359.
    Abstract:
    Patients with renal insufficiency have an increased risk of hepatitis B infection and a high probability to develop a chronic course of this disease. After hepatitis B vaccination they are known to show a low rate of seroconversion. In the present study we assessed the efficacy of a new recombinant pre-S1 and pre-S2 containing hepatitis B vaccine in 17 non-responders (anti-HBs titer 0) and 4 low-responders (anti-HBs titer < or = 5 IU/ml) with chronic renal insufficiency (16 on chronic hemodialysis therapy and 5 without hemodialysis treatment). Seroconversion rate was 65% after the third and 71% after the fourth vaccination. Only minor side effects were seen. These results encourage to use the new vaccine in a larger number of patients with renal insufficiency.
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