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  • Title: [Computed sonography observation on the effects of cimetidine on the liver blood flow in cirrhotic patients with portal hypertension].
    Author: Li S, Hou H, Leng X.
    Journal: Zhonghua Wai Ke Za Zhi; 1995 Aug; 33(8):466-9. PubMed ID: 8706560.
    Abstract:
    The effects of cimetidine on the hepatic and portal vein blood flow were investigated in 20 cirrhotic patients with portal hypertension by computed sonography. Cimetidine given intravenously at a dose of 0.4g significantly increased the hepatic vein blood flow (60.2% +/- 63.6%, P < 0.01), at the same time its calculated cross section area increased by 40.2% +/- 81.3% (P < 0.01). The portal vein blood flow increased by 53.2% +/- 52.3% (P < 0.01). While its cross section area was 16.8% +/- 17.3% (P < 0.01). These results showed that the histamine H2-receptor antagonist cimetidine may dilate liver vascular bed and reduce portal blood flow resistance in cirrhotic patients with portal hypertension.
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