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  • Title: The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase.
    Author: Hrabák A, Bajor T, Temesi A, Mészáros G.
    Journal: FEBS Lett; 1996 Jul 22; 390(2):203-6. PubMed ID: 8706860.
    Abstract:
    Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea. Arginase was inhibited by nitrite, the stable end product of NO. This inhibition was non-competitive, and could not be explained by the reaction of nitrite with arginine, or by the irreversible covalent modification of arginase, or by the removal of Mn2+, a cofactor of arginase.
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