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  • Title: Positive chronotropic and negative inotropic actions of vasopressin in isolated blood-perfused canine atrium.
    Author: Chiba S.
    Journal: Jpn Heart J; 1977 Mar; 18(2):221-4. PubMed ID: 870730.
    Abstract:
    Effects of vasopressin on SA nodal pacemaker activity and atrial contractility were investigated, using 5 isolated, blood-perfused canine atrium preparations. Vasopressin produced a dose-related positive chronotropic and negative inotropic effect, which was not influenced by treatments with an adequate dose of atropine or an adrenergic beta-blocking agent, alprenolol. From these results, it is concluded that vasopressin has a direct stimulating property on SA nodal pacemaker activity and a direct suppressive property on atrial contractility.
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