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  • Title: Antifungal susceptibility testing using the E test: comparison with the broth macrodilution technique.
    Author: Chen SC, O'Donnell ML, Gordon S, Gilbert GL.
    Journal: J Antimicrob Chemother; 1996 Feb; 37(2):265-73. PubMed ID: 8707736.
    Abstract:
    The National Committee for Clinical Laboratory Standards reference broth macrodilution method for antifungal susceptibility testing was compared with the E test by testing 86 clinical isolates of Candida spp. and Cryptococcus neoformans. The MIC agreement rates for the two methods for Candida spp. were 73-89% within +/-1 doubling dilution and 87-100% within +/-2 dilutions. For C. neoformans, agreement within +/-1 dilution was > 70% for all the agents tested except fluconazole for which agreement was 35%. Our data support the further evaluation of the E test as an alternative method for antifungal susceptibility testing. However, E test MICs of fluconazole for C. neoformans, particularly C. neoformans var. gattii should be interpreted with caution, as falsely elevated MICs may occur.
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