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  • Title: Comparative in-vitro activity of SCH 27899, a novel everninomicin, and vancomycin.
    Author: Urban C, Mariano N, Mosinka-Snipas K, Wadee C, Chahrour T, Rahal JJ.
    Journal: J Antimicrob Chemother; 1996 Feb; 37(2):361-4. PubMed ID: 8707748.
    Abstract:
    The antibacterial activity of SCH 27899, was compared with vancomycin in vitro against 210 recent clinical isolates representing eight major genera of Gram-positive organisms. MIC90 values for everninomicin were consistently better than those of vancomycin for all Gram-positive bacteria tested. Although everninomicin was less bactericidal than vancomycin against staphylococci, it was inhibitory against vancomycin-resistant enterococci. This novel antibiotic may, therefore, provide a clinical alternative to penicillin and vancomycin for therapy of Gram-positive infections.
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