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  • Title: Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex.
    Author: Moses MJ, Russel LB, Cacheiro NL.
    Journal: Science; 1977 May 20; 196(4292):892-4. PubMed ID: 870966.
    Abstract:
    Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.
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