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Pubmed for Handhelds

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  • Title: Molecular handles on adaptive mutation.
    Author: Rosenberg SM, Harris RS, Torkelson J.
    Journal: Mol Microbiol; 1995 Oct; 18(2):185-9. PubMed ID: 8709838.
    Abstract:
    In one experimental system, several handles on the molecular mechanism of apparent adaptive mutation have emerged. The system is reversion of a lac frameshift mutation in Escherichia coli. The molecular handles include a requirement for homologous recombination; the implication of DNA double-strand breaks as a molecular intermediate; a unique sequence spectrum of -1 deletions in mononucleotide repeats which implies polymerase errors, and also implies a failure of postsynthesis mismatch repair on those errors; and the involvement of sexual functions at some stage of the process. These molecular handles are revealing an unexpected new mechanism of mutagenesis.
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