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  • Title: Tranilast inhibits the effects of platelet-derived growth factor on cell proliferation and induction of nitric oxide.
    Author: Hishikawa K, Nakaki T, Hirahashi J, Marumo T, Saruta T.
    Journal: Eur J Pharmacol; 1995 Nov 30; 291(3):435-8. PubMed ID: 8719431.
    Abstract:
    The effects of tranilast on DNA synthesis and cell proliferation in cultured rat mesangial cells, treated with platelet-derived growth factor (PDGF), were investigated. Tranilast significantly inhibited PDGF-stimulated DNA synthesis and cell proliferation in a dose-dependent manner. In the absence of PDGF, it also enhanced cytokine-induced nitric oxide (NO) production, PDGF significantly inhibited cytokine-induced NO production, but tranilast completely abolished this inhibitory effect of PDGF. These results show that tranilast inhibits PDGF-induced proliferation of mesangial cells under both normal and inflammatory conditions.
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