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  • Title: [The effect of hemolysate and calcium ions on transport ATPase activity in guinea pig erythrocytes].
    Author: Matskevich IuA, Kazennov AM.
    Journal: Zh Evol Biokhim Fiziol; 1994; 30(6):738-45. PubMed ID: 8721317.
    Abstract:
    Influence of 0.1, 0.3 and 1.0 microM Ca++ on Na,K-ATPases in different membrane preparations of guinea pig erythrocytes was studied both in presence and in absence of haemolysate. The incubation with the haemolysate and 0.1 or 0.3 microM Ca++ increased significantly the activity of the Na,K-ATPase in all membrane preparations used. The increasing Ca++ concentrations (up to 1 microM) led to the loss of the activating effect of the haemolysate in membrane preparations with lack of a part of the cytoskeleton proteins, and also decreased sharply its activity in all the preparations in absence of haemolysate. The latter also increased the Ca-ATPase activity irrespectively of the integrity of cytoskeleton structures (may be because of calmodulin action). The results obtained suggest that the cytoskeleton structures mediate the intracellular Na,K-ATPase activator action.
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