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  • Title: Failure of an antagonist of histamine--chlorpheniramine--to modify the pulmonary vascular response to hypoxia in chronic bronchitis.
    Author: Stark RD, Joshi RC, Bishop JM.
    Journal: Cardiovasc Res; 1977 May; 11(3):219-22. PubMed ID: 872161.
    Abstract:
    Experimental evidence from animals suggests that the response of the pulmonary circulation to hypoxia is mediated by histamine. In 3 patients with chronic bronchitis the pulmonary vascular response to hypoxia was measured before and after administration of chlorpheniramine, a competitive antagonist of histamine. No convincing evidence was obtained of a reduction in the size of the response to hypoxia.
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