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  • Title: Experimental autoimmune hepatitis in mice following immunization with syngeneic liver proteins.
    Author: Mihas AA, Subramony C, Achord JL.
    Journal: J Med; 1995; 26(5-6):309-22. PubMed ID: 8721906.
    Abstract:
    In this study, we describe the successful induction of experimental autoimmune hepatitis by immunizing inbred strains of mice with syngeneic liver antigens. Hepatic lesions, presumably based on autoimmune mechanisms, induced after 3 weekly immunizations were of only moderate degree. Of the various mouse strains used, C57BL/6 mice showed the most prominent histological changes of the liver, which were accompanied by elevated serum alanine aminotransferase levels. This system offers a potential model for further investigating experimental autoimmune hepatitis.
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