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  • Title: Comparative in-vitro activity of CP-99219, a new quinolone, against respiratory pathogens.
    Author: Sefton AM, Maskell JP, Seymour AC, Minassian M, Williams JD.
    Journal: J Antimicrob Chemother; 1996 Apr; 37(4):803-8. PubMed ID: 8722546.
    Abstract:
    The comparative in-vitro activity of CP-99219, a new quinolone, against Haemophilus influenzae (150 isolates), Moraxella catarrhalis (100), Streptococcus pneumoniae (80) and Group A beta-haemolytic streptococci (40) was determined using an agar dilution technique. CP-99219 was the most active compound tested against M. catarrhalis (MIC50 = 0.015 mg/L, MIC90 = 0.03 mg/L). Ceftriaxone, CP-99219 and ciprofloxacin were the three most active agents tested against H.influenzae. CP-99219 showed good activity, 16-fold greater than that of ciprofloxacin, against S.pneumoniae (MIC50 = 0.12 mg/L; MIC90 = 0.25 mg/L) and was also active against Group A streptococci. Clinical studies regarding the use of CP-99219 in respiratory tract infections seem indicated.
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