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  • Title: Differentiating agents do not induce a true hairy cell phenotype in B-CLL cells in vitro.
    Author: Gartenhaus R, Hoffman M, Fuchs A, Billet H, Wang P, Gentile P, Rai K.
    Journal: Leuk Lymphoma; 1996 Jun; 22(1-2):97-101, follow.186, color plate IX. PubMed ID: 8724534.
    Abstract:
    B-Chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) are both differentiated B-cell lymphoproliferative disorders. Prior studies have suggested that phorbol esters and the macrocyclic lactone Bryostatin-1, which are both protein kinase-C activators, can induce the differentiation of B-CLL cells into HCL cells in vitro, as evidenced by morphology, phenotype and TRAP activity. The differentiating effect of all-trans retinoic acid on B-CLL cells has been less extensively studied. We studied the effects of incubating adherence purified B-CLL cells with phorbol myristic acetate (PMA), all-trans retinoic acid (ATRA), and Bryostatin-1. None of these agents induced a true HCL phenotype (CD5-, CD11c/CD25 coexpression) under the conditions studied.
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