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  • Title: Human papillomavirus in a patient with severe gingival overgrowth associated with cyclosporine therapy. A case report.
    Author: Sağlam F, Onan U, Soydinç M, Yilmaz O, Kiraç K, Sever MS.
    Journal: J Periodontol; 1996 May; 67(5):528-31. PubMed ID: 8724712.
    Abstract:
    Cyclosporin a is an endecapeptide that has been used clinically since 1978 as an immunosuppressant agent. Although cyclosporine appears to be uniformly beneficial in the treatment of a wide variety of disorders, its use may result in a number of side effects. One of the most important adverse effects is gingival overgrowth. This report relates a case of severe gingival overgrowth in a 31-year-old female who had received cyclosporine therapy in conjunction with a kidney transplant. Because of the severe gingival overgrowth, we analyzed a biopsy, which was positive for human papillomavirus. The case was treated and followed for 18 months.
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