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  • Title: Ampullary somatostatinoma in a patient with von Recklinghausen's disease.
    Author: Kainuma O, Ito Y, Taniguchi T, Shimizu T, Nakada H, Date Y, Hara T.
    Journal: J Gastroenterol; 1996 Jun; 31(3):460-4. PubMed ID: 8726843.
    Abstract:
    We report a case of somatostatinoma of the ampulla of Vater associated with von Recklinghausen's disease in a 44-year-old woman. On admission the patient was jaundiced, and percutaneous Cholangio-drainage was performed. Cholangiography revealed stenosis of the common bile duct at the lower end Duodenoscopy showed a yellowish tumor of the ampulla of Vater, and the biopsy specimens showed no malignant cells. Pylorus-preserving pancreaticoduo-denectomy was performed. Histologically, the tumor was composed of small round cells with a solid or trabecular pattern and with multiple psammoma bodies. Immunohistochemical examination showed that the tumor cells stained for somatostatin. Genomic examination showed neither K-ras nor p53 gene mutations of the resected specimen.
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