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  • Title: [Primary myelofibrosis with severe bone pain].
    Author: Kikukawa M, Arie Y, Kuramoto K, Tsutsumi H, Hirai M, Kumakawa T, Sawabe M, Mori M.
    Journal: Rinsho Ketsueki; 1996 Mar; 37(3):228-32. PubMed ID: 8727347.
    Abstract:
    An 80-year-old man was admitted with bone pain, affecting both lower limbs and the dorsa of the feet, in September, 1991. Primary myelofibrosis was diagnosed. Bilateral x-ray films of the tibia, fibula, femur and vertebra revealed osteoporosis, but this was considered an unlikely source of the bone pain. The bone pain subsequently disappeared, but then became severe in both lower limbs and the dorsa of the feet and was accompanied by leukemic transformations in February, 1992. He died of aspiration pneumonia in July, 1992. Autopsy revealed microfractures with osteoporosis and infiltration of leukemic cells in the periosteum of the left tibia, which may have caused the bone pain. This case provides useful information to analyze the cause of bone pain in patients with myelofibrosis.
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