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  • Title: Action of some natural polypeptides on the longitudinal muscle of the guinea pig ileum.
    Author: Széli J, Molina E, Zappia L, Bertaccini G.
    Journal: Eur J Pharmacol; 1977 Jun 01; 43(3):285-7. PubMed ID: 872882.
    Abstract:
    The structure--activity relationship of some natural tachykinins was investigated in the longitudinal muscle of the guinea pig ileum. The order of potency was eledoisin greater than uperolein greater than substance P greater than phyllomedusin greater than physalaemin. This ratio of activity is different from that observed in other experimental conditions, and in different in vivo or in vitro preparations; it is suggested that the N-terminal part of the molecule of the tachykinins plays a role in determining the degree of potency of these compounds.
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