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  • Title: Pneumocystis carinii pneumonia in childhood systemic lupus erythematosus.
    Author: Foster HE, Malleson PN, Petty RE, Roberton DM, Cabral DA.
    Journal: J Rheumatol; 1996 Apr; 23(4):753-6. PubMed ID: 8730139.
    Abstract:
    OBJECTIVE: Although Pneumocystis carinii pneumonia (PCP) is known to occur in adults with systemic lupus erythematosus (SLE), this infection has rarely been described in childhood SLE. We describe 3 children with SLE who developed PCP and describe risk factors for this complication. METHODS: A retrospective case review. RESULTS: All 3 children had severe active SLE with organ involvement requiring immunosuppressive therapy, but the clinical presentations of PCP differed in each patient. They shared some of the known risk factors for opportunistic infection in adults with SLE, including lymphopenia, but severe lymphopenia (< 0.35 x 10(9)/1) was not seen. CONCLUSION: PCP is an uncommon but serious complication of childhood SLE, and should be considered in the presence of respiratory symptoms, however subtle. The role of oral chemoprophylaxis is discussed.
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