These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Carbamazepine augmentation therapy in three patients with trazodone-resistant unipolar depression.
    Author: Otani K, Yasui N, Kaneko S, Ohkubo T, Osanai T, Sugawara K.
    Journal: Int Clin Psychopharmacol; 1996 Mar; 11(1):55-7. PubMed ID: 8732315.
    Abstract:
    In three patients with trazodone-resistant unipolar depression, carbamazepine 400 mg/day was co-administered for 4 weeks. They all showed favourable responses; two non-delusional patients completely or almost recovered, while one delusional patient showed considerable improvement in depressive symptoms other than delusions of guilt. Plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine (m-CPP) were decreased, while the m-CPP/trazodone ratio was increased in all cases. The present report suggests that carbamazepine augments antidepressant effects of trazodone by an enhancement of serotonin function.
    [Abstract] [Full Text] [Related] [New Search]