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  • Title: The association of HL-A-B8 and childhood celiac disease in an Israeli population.
    Author: Gazit E, Avigad S, Zfat Z, Efter T, Mizrachi Y, Rotem Y.
    Journal: Isr J Med Sci; 1977 Apr; 13(4):400-4. PubMed ID: 873760.
    Abstract:
    The frequency of histocompatibility antigens (HL-A) was studied in 33 children with celiac disease. HL-A-B8 phenotype was detected in 27.3% of the celiac patients and 7.5% of 395 carefully matched control subjects (X2 for heterogeneity=14.23; P less than 10(-4)). HL-A typing, especially in children, is advocated both as a diagnostic and a prognostic measure. The importance of ethnically matched control subjects is discussed together with a proposal for the construction of such control groups.
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