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  • Title: High-dose radiation-induced meningiomas following acute lymphoblastic leukemia in children.
    Author: Salvati M, Cervoni L, Artico M.
    Journal: Childs Nerv Syst; 1996 May; 12(5):266-9. PubMed ID: 8737803.
    Abstract:
    The authors review three personal cases of patients who developed cerebral meningiomas following high-dose radiotherapy for acute lymphoblastic leukemia. Two patients were female and one male. Their ages when the leukemia appeared were between 11 and 15 years. All patients were treated with a course of prophylactic irradiation to the neuraxis for a total dose of 24 Gy. After an average interval of 10.4 years, all three patients presented a meningioma; histologically, one was meningothelial and two were fibrous. All three meningiomas presented atypical features. At follow-up 1, 4, and 4 years respectively after surgery, none of these patients presents neurological deficits or neuroradiological signs of recurrence. Forty-nine cases of high-dose radiation-induced meningioma are also reviewed.
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