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  • Title: Synaptotagmin II immunoreactivity in normal and botulinum type-A treated mouse motor nerve terminals.
    Author: Juzans P, Molgo J, Faille L, Angaut-Petit D.
    Journal: Pflugers Arch; 1996; 431(6 Suppl 2):R283-4. PubMed ID: 8739375.
    Abstract:
    The distribution of synaptotagmin II, a synaptic vesicle protein, was examined by immunohistochemistry at normal mouse motor nerve terminals and after botulinum type-A treatment. An immunoreactivity to synaptotagmin II was detected in both control and botulinum type-A treated motor nerve terminals including newly formed sprouts. These data, together with other reports showing the absence of synaptotagmin I at the neuromuscular junction, suggest that synaptotagmin II is the isoform involved in transmitter release at motor nerve terminals.
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