These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Histamine-evoked potassium release in the mouse and guinea pig pancreas.
    Author: Rosado JA, Tapia JA, García LJ, Salido GM.
    Journal: Pancreas; 1996 May; 12(4):396-400. PubMed ID: 8740408.
    Abstract:
    An investigation was made of the effects of histamine on the K+ concentration in the effluent in superfused guinea pig and mouse pancreatic segments. The effect of acetylcholine (ACh) was examined for comparison. Histamine evoked a dose-dependent and transient increase in the K+ concentration in the effluent (K+ release) but is less potent compared to the cholinergic agonist, ACh. At the same doses histamine and ACh evoke a much larger K+ release from mouse superfused pancreatic segments followed in the poststimulus period by a reuptake of K+. However, this reuptake of K+ was not observed in guinea pig superfused pancreatic segments. On the other hand, the cholinergic antagonist, atropine, completely abolished the K+ release in response to ACh and histamine from mouse and guinea pig pancreatic segments. Our results show the involvement of histamine in the control of K+ release in pancreatic tissue, with significant differences in the observed responses between species.
    [Abstract] [Full Text] [Related] [New Search]