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  • Title: Ventilatory response to cholecystokinin tetrapeptide in anaesthetized dogs.
    Author: Bates JH, Bradwejn J.
    Journal: Neuroreport; 1995 Dec 15; 6(18):2513-7. PubMed ID: 8741752.
    Abstract:
    Cholecystokinin (CCK) has been implicated in the genesis of panic disorder. In this study we measured the ventilatory response to i.v. injection of CCK-tetrapeptide (CCK-4) in anaesthetized dogs. We found an immediate and transient increase in minute ventilation. The response was large (more than 100% of baseline) and lasted 1-2 min. Repeated CCK-4 injection produced a somewhat reduced response, suggestive of a slight degree of tachyphylaxis. Blood pressure and heart rate changed only slightly (<10%), while respiratory mechanical parameters remained unchanged following CCK-4 administration. We conclude that CCK-4 has a significant effect on ventilation in the anaesthetized dog, which suggests that this species may provide a useful quantitative assay for the anxiogenic effects of CCK.
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