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  • Title: [Brunner's gland adenoma of the duodenal bulb].
    Author: Smirnov OA, Serezhin BS, Nikonova OA.
    Journal: Arkh Patol; 1995; 57(6):71-3. PubMed ID: 8742193.
    Abstract:
    This rare tumor was found at surgery in a 35-year-old male operated for chronic ulcer of the duodenum complicated by gastrointestinal bleeding. The tumor looked like a pedunalated polyp 6 x 3 x 2 cm in size with an ulcer 0.5 cm in diameter. Histologically, the tumor was formed of large lobules of Brunner's glands, and its surface was lined with intestinal villi. Pascual's argyrophilic test discovered focal hyperplasia of endocrine cells in the intestinal lining. The majority of these cells, according to PAP reactions with antisera to polypeptides, were serotonin-positive. Among tumor cells somatostatine-positive cells were most numerous.
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