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  • Title: Severe barbiturate withdrawal syndrome in migrainous patients.
    Author: Raja M, Altavista MC, Azzoni A, Albanese A.
    Journal: Headache; 1996 Feb; 36(2):119-21. PubMed ID: 8742687.
    Abstract:
    Three patients who presented with grand mal seizures and an associated behavioral disorder were recognized as suffering from a severe butalbital withdrawal syndrome. All were migraineurs who had become dependent on barbiturates. We propose that the occurrence of seizures, psychotic behavior, or a recent personality change should be considered clues to possible barbiturate abuse in patients with migraine.
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