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  • Title: [Methods for diagnosing the physiopathological mechanisms of bronchial obstruction].
    Author: Kuznetsova AG, Larin NV, Ivanov AV.
    Journal: Ter Arkh; 1996; 68(3):62-5. PubMed ID: 8744109.
    Abstract:
    This study aimed at clarification of pathophysiological mechanisms underlying bronchial obstruction in 28 18-71-year-old patients with chronic bronchitis (CB) diagnosed 2-8 years before. The patients had moderate obstructive disorders in distal parts of the bronchial tree. Investigations revealed a group of patients with paradoxical response to beta-blockers manifesting as lowering of bronchial resistance and high speed. Bronchial obstruction in these patients proved to arise primarily from early expiratory collapse of small bronchi. Administration of beta-mimetic and beta-blocking agents may serve as pharmacological tests able to discover mechanisms of bronchial obstruction and help in the choice of adequate therapy for chronic bronchitis.
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